Potential New Therapeutic Targets for Pathological Pruritus

Fibrocytes: potential new therapeutic targets for pulmonary hypertension?

New Enzymes as Potential Therapeutic Targets for Trypanosomiases and Leishmaniasis

1Department of Molecular Biology of Trypanosoma cruzi, Instituto de Investigaciones Medicas Alfredo Lanari (IDIM, UBA-CONICET), Avenida Combatientes de Malvinas 3150, 1427 Buenos Avies, Argentina 2 Instituto de Ciencias Biomedicas, Universidade de São Paulo, Av. Lineu Prestes 1374, Cidade Universitária Butanta, São Paulo, CEP 05508-900, Brazil 3Deptartemento Biologia Celular e Inmunologia, Inst...

New targets for new therapeutic approaches

Because of its resistance profiles, Pseudomonas aeruginosa remains probably one of the challenging bacteria responsible for ventilator-associated pneumonia in the ICU. Nevertheless, a much better understanding of its mechanism of virulence, such as the type 3 secretion system that can also impact on resistance, gives some opportunities for management improvement. The most promising approach is ...

New antiherpesvirus agents. Their targets and therapeutic potential.

Of the large number of agents under development for the treatment of herpes virus infections [herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV)], only ten have apparently reached clinical development. Aciclovir was approved for the treatment of HSV infections over 10 years ago, and it remains an important and reli...

Giant cell arteritis: pathogenic mechanisms and new potential therapeutic targets

Giant cell arteritis (GCA) is the most common idiopathic systemic vasculitis in persons aged 50 years or greater. Treatment options for GCA, to-date, have been limited and have consisted primarily of glucocorticoids. Significant advances in the understanding of the genetic and cellular mechanisms in GCA are leading to identification of potential pathogenic targets. The recent success of interle...